卞希玲 博士，北京大学药学院分子与细胞药理学系副研究员。研究方向为寻找新的神经递质。2002年至2008年期间在中国科学院上海神经科学研究所，北京生命科学研究所，中国科学院生物物理研究所进行硕博连读学习，师从李朝义院士和罗敏敏研究员。2008年获得中国科学院生物物理研究所博士学位后，进入北京大学医学部，2008年到2018年在王克威实验室从事离子通道领域的研究工作。目前从事寻找新的神经递质的研究工作。承担 “国家自然基金（面上基金）”，“国家自然基金（青年基金）”，“北京市青年英才计划”等基金6项，参与基金9项。以第一作者/共同第一作者的身份在《自然-通讯》《elife》等杂志发表SCI研究论文7篇，其它作者参与发表论文12篇。教学方面负责《如何阅读科研文献》等课程，累计为200名本科生进行一对一文献辅导。曾被评选为北京大学医学部优秀教师，荣获北京大学医科类青年教师讲课比赛三等奖，药学院青年教师讲课比赛二等奖，基础医学院青年教师讲课比赛三等奖，医学部公会征文美文奖二等奖，青年教授讲课比赛三十周年征文一等奖。曾培养多名本科毕业生进入哈佛大学，密西西比大学，德国洪堡大学和美国加州大学伯克利分校等名校攻读硕士/博士。Email: bianxiling@bjmu.edu.cn。
发表论文
1. Xiling Bian#, Jiemin Zhu#, Xiaobo Jia#, Wenjun Liang, Sihan Yu, Zhiqiang Li, Wenxia Zhang, Yi Rao*, Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology, ELife , 2023 Dec 21:12:RP89317 doi: 10.7554/eLife.89317. 该文章被eLife杂志的”Central Nervous System: Is creatine a CNS neurotransmitter?” 专文评述。（第一作者）(IF 6.4，2023年影响因子)
2.Xiaobo Jia# , jiemin Zhu#, Xiling Bian#, Sulin Liu, Wenjun Liang, Jiang L, Mao R, Zhang W, Rao Y*, Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability. Elife. 2023 Jul 13;12:RP86972. Doi : .7554/eLife.86972.PMID: 37440432 （共同第一作者）(IF 6.4，2023年影响因子)
3.Xiling Bian*, Yu Zhang, Bin Huang, Xintong Wang, Y Zhu, Gongxin Wang, Yan Liu, Jianhui Liang, Yanxing Jia*, Kewei Wang*, Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents. Eur J Pharmacol. 2019 Sep 5;858:172496. doi: 10.1016/j.ejphar.2019.172496. Epub 2019 Jun 23.PMID: 31242440 （第一作者，共同通讯作者）(IF 4.4)
4. Xiling Bian*, Physiological and morphological characterization of GABAergic neurons in the medial amygdala, Brain Reserch.(2013); 1509:8-19（第一作者，通讯作者）(IF 2.7)
5. Limin Shi＃, Xiling Bian＃, Zhiqiang Qu, Zegang Ma, Yu Zhou, KeWei Wang*, Hong Jiang* & Junxia Xie*, Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels ,NATURE COMMUNICATIONS, (2013), 4:1435 （共同第一作者）(IF 14.7)
6. Zhenyu Hu＃, Xiling Bian＃, Xiaoyan Liu, Yuanjun Zhua, Xiaoyi Zhang, Shizhong Chen, Kewei Wang, YinyeWanga*, Honokiol protects brain against ischemia–reperfusion injury in rats through disrupting PSD95–nNOS interaction, Brain Reserch,1491,(2013) 204-212（共同第一作者）(IF 2.7)
7. Xiling Bian, Yuchio Yanagawa, Wei R. Chen, Minmin Luo, Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala, J Neurophysiol, (2008),99(1),77-86（第一作者）(IF 4.35)
8. Chenxia Yang,＃Ying Meng,＃ Xintong Wang,＃Xin Li, Tong Yu, Weiming Liao, Wenjun Xie, Qianchen Jiang, Han Wang, Cheng Shi, Wenxuan Jiao, Xiling Bian, Fang Hu, Xiaowei Wang, Yani Liu, Liangren Zhang, KeWei Wang,* and Qi Sun*, Allosteric Activation of α7 Nicotinic Acetylcholine Receptors by Novel 2‑Arylamino-thiazole-5-carboxylic Acid Amide Derivatives for the Improvement of Cognitive Deficits in Mice, J. Med. Chem. 2024, 67, 6344−6364 (IF 6.8)
9. Yan Liu*, Liang Shan, Tianer Liu, Juan Li, Yongchang Chen, Changhong Sun, Chaojuan Yang, Xiling Bian,Yuyu Niu , Chen Zhang , Jianzhong Xi, Yi Rao*,Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin. Neuron. 2023 May 3;111(9):1468-1485.e7. doi: 0.1016/j.neuron.2023.02.010. Epub 2023 Mar 2.PMID: 36868221 (IF 14.7)
10. Xintong Wang, Haoran Xiao, Jing Wang, Zongze Huang, Geng Peng, Wenjun Xie, Xiling Bian, Huijie Liu, Cheng Shi, Taoyi Yang, Xin Li, Jian Gao, Ying Meng, Qianchen Jiang, Wei Chen, Fang Hu, Ningning Wei, Xiaowei Wang, Liangren Zhang, KeWei Wang*, Qi Sun*. Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors. J Med Chem. 2021 Aug 26;64(16):12379-12396.
11.Yuanheng Li , Lilan Sun , Taoyi Yang , Wenxuan Jiao, Jingshu Tang , Xiaomin Huang , Zongze Huang , Ying Meng, Laichun Luo , Xintong Wang , Xiling Bian , Fang Zhang, KeWei Wang*, Qi Sun*, Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice. J Med Chem. 2019 Jan 10;62(1):159-173. doi: 10.1021/acs.jmedchem.7b01492. Epub 2018 Apr 9.PMID: 29587480 (IF 6.67)
12. Xin Li, Wenjun Xie, Xintong Wang, Zongze Huang, Xiling Bian, KeWei Wang *, Qi Sun*,Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs,Bioorg Med Chem Lett, 2019 Aug 1;29(15):1928-1933. doi: 10.1016/j.bmcl.2019.05.046. Epub 2019 May 22. (IF 2.5)
13. Hui Peng , Xiling Bian , Fucui Ma, Kewei Wang, Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices. Acta Pharmacol Sin, 2017 Sep;38(9):1248-1256. doi: 10.1038/aps.2017.72. Epub 2017 Jun 12. (IF 6.9)
14. Qingqing Cao, Wei Wang, Juan Gu , Guohui Jiang, Xiling Bian , Kewei Wang, Zucai Xu, Jie Li , Guojun Chen, Xuefeng Wang*, Elevated Expression of Acid-Sensing Ion Channel 3 Inhibits Epilepsy via Activation of Interneurons. Mol Neurobiol. 2016 Jan;53(1):499. doi: 10.1007/s12035-015-9100-y.PMID: 25875865 (IF 4.6)
15. Jingshu Tang , Bingxue Xie, Xiling Bian, Yu Xue, Ning-ning Wei, Jing-heng Zhou , Yu-chen Hao, Gang Li, Liangren Zhang, Ke-wei Wang. Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.Acta Pharmacol Sin, 2015 Jul;36(7):800-12. doi: 10.1038/aps.2015.9. Epub 2015 Apr 27. (IF 6.9)
16. Yi-Quan Tang, Ping Liang, Jingheng Zhou, Yanxin Lu, Lei Lei, Xiling Bian, KeWei Wang *, Auxiliary KChIP4a Suppresses A-type K+ Current through Endoplasmic Reticulum (ER) Retention and Promoting Closed-state Inactivation of Kv4 Channels, JOURNAL OF BIOLOGICAL CHEMISTRY, (2013),288(21), pp 14727-14741,2013/5/24 (IF 3.92)
17. Yeping Bi, Hui Chen, Jun Su, Xu Cao, Xiling Bian and KeWei Wang*, Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice, Molecular Pain ,2011, 7:84 (IF 2.8)
18. Yanni Liu, Xiling Bian, Kewei Wang, Pharmacological Activation of Neuronal Voltage-Gated Kv7/KCNQ/M-Channels for Potential Therapy of Epilepsy and Pain. Handb Exp Pharmacol. 2021;267:231-251. doi: 10.1007/164_2021_458.PMID: 33837465（IF 6.1）
19. Xiling Bian, Targeting voltage-gated Kv7/KCNQ/M-channel for therapeutic potential of neuropsychiatric disorders, Journal of Chinese Pharmaceutical Sciences, (2014),vol 23, pp 4-1（封面文章）
