纪德重，副研究员，北京大学宁波海洋药物研究院生物中心执行主任。获博士后创新人才计划、国自然基金委面上、青年基金，科技部国家重点研发计划（2024YFA0917500），国家重点研发计划颠覆性技术创新（2025YFF1502800）支持。在Nature Biotechnology，Nature Biomedical Engineering，Advanced Science等杂志发表多篇SCI论文。研究成果入选《中国2023年度重要医学进展》。
研究方向：流感病毒工程化、细胞因子药物，肿瘤免疫治疗。
研究论文：
1.Dezhong Ji*, Yuanjie Zhang, Jiaqi Sun, Bo Zhang, Wenxiao Ma, Boyang Cheng, Xinchen Wang, Yuanhao Li, Yu Mu, Huan Xu, Qi Wang, Chuanling Zhang, Sulong Xiao, Lihe Zhang, Demin Zhou*. An engineered influenza virus to deliver antigens for lung cancer vaccination. Nature Biotechnology, 2023, 42: 518-528. (co-first author, co-corresponding author)
2.Yuanjie Zhang, Zhiqian Chen, Xiaoyang Wang, Rongding Yan, Han Bao, Xindang Chu, Lingfeng Guo, Xinchen Wang, Yuanhao Li, Yu Mu, Qiuchen He, Lihe Zhang, Chuanling Zhang, Demin Zhou*, Dezhong Ji*. Site-specific tethering nanobodies on recombinant adeno-associated virus vectors for retargeted gene therapy. Acta Biomater 2024, 187, 304-315. (co-corresponding author)
3.Jiaqi Sun, Lingfeng Guo, Dezhong Ji*, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang*, Demin Zhou*. Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates. Adv Sci 2025, 12(18):2414931. (co-first author, co-corresponding author)
4.Bo Zhang, Jiaqi Sun, Yan Wang, Dezhong Ji, Yeshuang Yuan, Shengjie Li, Yeting Sun, Yingqin Hou, Pengchong Li, Lidan Zhao, Fei Yu, Wenxiao Ma, Boyang Cheng, Ling Wu, Jin Hu, Min Wang, Wei Song, Xiaogang Li, Hao Li, Yunyun Fei, Hua Chen, Lihe Zhang, George C. Tsokos, Demin Zhou*, Xuan Zhang*. Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells. Nature Biomedical Engineering, 2021, 5: 1222-1305. (co-first author)
5.Bo Zhang, Jiaqi Sun, Yeshuang Yuan, Dezhong Ji, Yeting Sun, Yudong Liu, Shengjie Li, Xingxing Zhu, Xunyao Wu, Jin Hu, Qiu Xie, Ling Wu, Lulu Liu, Boyang Cheng, Yuanjie Zhang, Lingjuan Jiang, Lidan Zhao, Fei Yu, Wei Song, Min Wang, Yue Xu, Shiliang Ma, Yunyun Fei, Lihe Zhang, Demin Zhou, Xuan Zhang. Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity. Signal Transduction and Targeted Therapy, 2023, 8. (co-first author)
